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Embryo Report

Advanced genetic screen for your embryos. Prevent your child from inheriting a predisposition to a condition that runs in your family.

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Couple Report

Our preconception test measures your future child's genetic predisposition to disease. Mitigate your risk.

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Whitepapers

Technical deep-dives validating Orchid's genetic risk scores and whole-genome screening methods.

AllQuick Guides76Fertility & Pregnancy45Genetics30Whitepapers25Patient Guides20Company News12Patient Perspectives10Clinician Perspectives3Case Reports1
Whitepaper: Validating Orchid’s Class III Obesity Genetic Risk Score

Whitepapers · 6 min read

Whitepaper: Validating Orchid’s Class III Obesity Genetic Risk Score

Orchid's reports include a genetic risk score (GRS) for class III obesity, validated on UK Biobank data. We share our methods and findings, including how the sc…

Whitepaper: Validating Orchid’s Type 1 Diabetes Genetic Risk Score

Whitepapers · 7 min read

Whitepaper: Validating Orchid’s Type 1 Diabetes Genetic Risk Score

Orchid's reports include a genetic risk score (GRS) for type 1 diabetes, validated on UK Biobank data. We share our methods and findings, including how the scor…

Whitepaper: Validating Orchid’s Type 2 Diabetes Genetic Risk Score

Whitepapers · 7 min read

Whitepaper: Validating Orchid’s Type 2 Diabetes Genetic Risk Score

Orchid's reports include a genetic risk score (GRS) for type 2 diabetes, validated on UK Biobank data. We share our methods and findings, including how the scor…

The Impact of Family History on the Lifetime Prevalence of Disease

Whitepapers · 15 min read

The Impact of Family History on the Lifetime Prevalence of Disease

A family history of a disease often increases the odds that a child develops the same disease. We explore how family history impacts disease risk and how embryo…

Improved Polygenic Prediction with Multi-Ancestry and Multi-Trait GWAS Data

Whitepapers · 16 min read

Improved Polygenic Prediction with Multi-Ancestry and Multi-Trait GWAS Data

We describe a method to improve the performance of genetic risk scores (GRS) across multiple ancestries – including European, East Asian, South Asian, and Afric…

Using Genetic Risk Scores to compare disease risk within families

Whitepapers · 9 min read

Using Genetic Risk Scores to compare disease risk within families

We show that genetic risk scores (GRS) developed on large population datasets retain their effectiveness when comparing the disease risk between embryos.

Estimating the single-gene disorder detection rate for PGT-WGS

Whitepapers · 19 min read

Estimating the single-gene disorder detection rate for PGT-WGS

We review the genetic basis of the conditions screened on Orchid’s panels and healthy adult whole-genome sequencing studies to estimate the rate at which PGT-WG…

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